Genomics of peritoneal surface malignancies

Authors

  • Jasvinder Singh Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD
  • Anup Sharma Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD
  • Nita Ahuja Departments of Surgery; Oncology and Urology, The Johns Hopkins University School of Medicine, Baltimore, MD

DOI:

https://doi.org/10.4081/joper.2017.62

Keywords:

Genomics, Peritoneal malignancies, peritoneal malignancies, Peritoneal carcinomatosis, peritoneal carcinomatosis, appendiceal neoplasm, peritoneal malignant mesothelioma, colorectal cancer

Abstract

Peritoneal malignancies and metastasis are traditionally approached as a terminal disease, however with multiple lines of clinical therapy; long-term survival can be achieved in selected patients using aggressive cytoreduction and hyperthermic intraperitoneal chemotherapy. This is especially true for Pseudomyxoma peritonei from appendiceal neoplasms, peritoneal mesothelioma and peritoneal metastasis from colorectal cancer. In this article, we discuss the nature of genomic alterations in these three peritoneal malignancies and their potential as prognostic and therapeutic markers in clinical decisions. Genomic characterization of malignancies using technological advances including what is now widely used and accepted next-generation genomic sequencing methods has identified genomic anomalies (i.e. mutations, epigenetic modifications, transcription and expression changes in RNA) which is used for targeted therapy, prognostication, surveillance and prediction of response to therapy.

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Author Biography

Nita Ahuja, Departments of Surgery; Oncology and Urology, The Johns Hopkins University School of Medicine, Baltimore, MD

Professor and Vice Chair of Research and Academic Affairs, Surgery,

Chief, Division of Surgical Oncology

Director of Surgical Oncology, Sidney Kimmel Comprehensive Cancer Center

 Johns Hopkins Medical Institutions

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Published

2017-07-12

How to Cite

1.
Singh J, Sharma A, Ahuja N. Genomics of peritoneal surface malignancies. J Peritoneum [Internet]. 2017 Jul. 12 [cited 2024 Nov. 21];2(2). Available from: https://joper.pagepress.net/index.php/joper/article/view/62

Issue

Vol 2, No 2 (2017)

Section

Original Articles from PSOGI Congress

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